Day one (25th Sep) : Theory  & practice

9.00–9.15 Welcome address
9.15–10.45 Hybrid modeling methods  1 (Introduction to hybrid modeling; Hybrid model structures; Identification methods; Indirect identification; sensitivities method; parameter estimation; cross-validation), Dr. Moritz v. Stosch and Prof. R. Oliveira
10.45-11.00 Coffee Break
11.00–12.30 Hybrid modeling methods  2  –  The general bioreactor hybrid model;  Deriving a bioreactor hybrid model for Escherichia coli, Dr. Moritz v. Stosch and Prof. R. Oliveira
12.30–13:30 Lunch
13.30–14.30 Introduction to the hybrid modeling toolbox,  Dr. Mark Dürkop
14.30–16.15 Hands on Hybrid modeling 1, Dr. Moritz v. Stosch, Dr. Mark Dürkop, MSc. José Pinto
16.15-16.45 Coffee Break
16.45–18.15 Hands on Hybrid modeling 2, Dr. Moritz v. Stosch, Dr. Mark Dürkop, MSc. José Pinto
19.30 Dinner and networking

Day two (26th Sep):  Theory & practice

9.00–10.30 Hybrid modeling methods 3 : Direct identification method; pruning methods hybrid model discrimination; bootstrap aggregation; prediction confidence intervals;  Dr. Moritz v. Stosch and Prof. R. Oliveira
10.30-10.45 Coffee Break
10.45–12.15 Hybrid model quality monitoring by the experience measure method; Dynamic optimization – optimal control method constrained by hybrid model reliability. Dr. Moritz v. Stosch and Prof. R. Oliveira
12.15–13.15 Lunch
13.15–14.30 Participants pitching their work
14.30–17.00 Hands on Hybrid modeling  3, Dr. Moritz v. Stosch, Dr. Mark Dürkop, MSc. José Pinto
17.00-17.30 Coffee Break
17.30–18.15 Industrial applications of hybrid modeling, Dr. Thomas Mrziglod (Bayer)
19.30 Sponsor Dinner

Hybrid modeling in the Industry 4.0 (27th Sep)

9.00-9.10 Welcome address
9.10-9.40 Data management in the industry 4.0, Martin Mayer, Eppendorf AG
9.40–10.10 Risk & Knowledge Management: Supporting Operational Excellence over Lifecycle in Biopharma Operations, Prof José C Menezes, IST
10.10-10.40 Scale-up of a reaction step from lab to commercial scale, switching from batch to continuous manufacturing using a mechanistic modelling approach, Dr. Filipe Ataide, Hovione 
10.40–11.00 Coffee Break
11.00–11.30 Title to be anounced,  Dr. Thomas Mrziglod (Bayer)
11.30–12:00 Structured data-driven approaches for process monitoring and prdictive anaçytics (to be confirmed, Prof Marcos Reis, Universidade de Coimbra
12.00–12.30 Applications of Hybrid Models for Downstream Processes: a Tangencial Flow Filtration Case Study, MSc Maximilian Krippl, BOKU University
12.30–13.30 Lunch
13.30-14.00 Towards model predictive control of CHO cultures, Dr. Wolfgang Sommeregger, Bilfinger AG
14.00–14.30 Using Hybrid Modeling and Intensified Design of Experiments  to Reduce Bioprocess Development and Characterization Times, Dr. Mark Dürkop, BOKU University
14.30–15.00 Hybrid modeling for culture media optimization, Prof. Rui Oliveira, FCTUNL
15:00-15.30 Coffee Break
15.30-16.00 Assembling an end-to-end framework for training, validation and deployment of hybrid models, Dr. Manfred Mücke,  Materials Center Leoben GmbH
16.00-16.30 Title to be confirmed, Dr. Moritz von Stosch, GSK Belgium
16.30-17.30 “Hybrid modeling in the industry 4.0” Panel Discussion & Closing Ceremony